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Studies on trimetoquinol—I: Distribution, excretion and metabolism of trimetoquinol

✍ Scribed by Teruhiko Meshi; Minezo Otsuka; Yoshishige Sato


Book ID
115770384
Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
938 KB
Volume
19
Category
Article
ISSN
0006-2952

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35S-Furosemide was administered to beagle dogs and rhesus monkeys in an oral solution on a single and a 20 repeated 5-mg/kg/day dosing regimen. Following the single dose, 25.0% (dogs) and 24.0% (monkeys) of the dose were excreted in the urine in 24 hr. TLC analysis demonstrated that both species had