Studies on the synthesis of the indole alkaloids pauciflorine A and B
β Scribed by Philip Magnus; Lewis Gazzard; Lindsay Hobson; Andrew H. Payne; Vince Lynch
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 212 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
A double Bischler-Napieralski reaction of the 11-membered ring carbamate 15 gave the homoannular diene 17 in a single step.
π SIMILAR VOLUMES
Tetracycles 3b-d, having the ABCD ring substructure of Strychnos alkaIoids and a &(formvhnethvl) substituent mokcted as an oxime or hvdraxone derivative. have been p&&d-by nu&phiIic addition of the enolate of indok.a&tic ester 1 to pyridinium salts 2b-d followed by acid cyclization. The same one-pot
A short, new route to the title tetracyclic substructure of Sf/cycho4 alkaloids, consisting in the nucleophilic attack of an ester a-anion to a pyridinium salt, acid-induced cyclization of the resultant 1,4\_dihydropyridine, and stereospecific elaboration of the ethylidene substituent, is reported.