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Studies on the synthesis of the azocino[4,3-b]indole framework and related compounds

✍ Scribed by Nesimi Uludag; Suleyman Patir

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
374 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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An efficient method for the synthesis of C‐4 position alkylated azocino[4,3‐b]indole 13 and 18 is described. Reduction of compounds 5, 6, 7 and 8 yielded the corresponding alcohols. Compounds 5, 6, 7 and 8 were synthesized through several steps starting from 1. The resulting alcohols underwent acid catalyzed ring closure to give tetracyclic azocino[4,3‐b]indole 9, 10, 11 and 12. Finally, compounds 9 and 17 were alkylated at C‐4 position to the corresponding products 13 and 18. The structure of the compounds 13 and 18 has been confirmed by X‐ray single crystal analysis.

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