Synthesis of the Azocino[cd]indole Framework through Pd-Catalyzed Intramolecular Acetylene Hydroarylation

✍ Scribed by Vsevolod A. Peshkov; Sofie Van Hove; Pavel A. Donets; Olga P. Pereshivko; Kristof Van Hecke; Luc Van Meervelt; Erik V. Van der Eycken

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 372 KB
• Volume: 2011
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201001669

✦ Synopsis

Abstract

The regio‐ and stereoselective construction of the azocino[cd]indole core was achieved by applying a Pd‐catalyzed intramolecular acetylene hydroarylation protocol. The applicability of a similar strategy for the synthesis of the azepino[b]indole framework is demonstrated.