Studies on the syntheses of hydrogenated quinolines and isoquinolines as analgesics—XVI : Synthesis of N-methyl-8-aza-des-N-morphinan (4-methyl-5:10b-trimethylene-1:2:3:4:4a:5:6:10b-octahydrobenzo [f] quinoline)

The synthesis of (−)-4-methyl-8-chloro-t

The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

✍ Fengjiun Kuo; William J. Wheeler 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 340 KB 👁 1 views

## Abstract The synthesis of the C‐14 labeled isotopomer of LY300502, a potent 5α‐reductase inhibitor has been accomplished in four radiochemical steps. The route involves the synthesis of LY300502‐[^14^C] from LY300502 __via__ a circuitous route; the label was introduced with ethyl chloroformate‐[