Studies on the secondary structure of nucleic acids by means of optical rotation
โ Scribed by P.O.P. Ts'o; G. Helmkamp
- Book ID
- 108372826
- Publisher
- Elsevier Science
- Year
- 1961
- Tongue
- French
- Weight
- 523 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0040-4020
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The melting temperature of a natural DNA is decreased in the presence of increasing amounts of copper ions, whereas other divalent metal ions stabilize the DNA secondary structure a t low ionic strength. At 1.28 X lO-4M, Cuz+ produces a decrease of T,,, depending on base composition. At very low Cu\
The first question that must be answered before the determination of the structure of nucleic acids can be carried out in earnest is: how much of what do they contain? It seemed to us that procedures suitable for this purpose had been lacking in the past and that no real progress was possible, unles