Studies on the Reduction of Aromatic Ketones by the Clemmensen Method
β Scribed by Bradlow, H. Leon; VanderWerf, Calvin A.
- Book ID
- 120586553
- Publisher
- American Chemical Society
- Year
- 1947
- Tongue
- English
- Weight
- 374 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0002-7863
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## Abstract Eleven structurally different Ξ±, Ξ²βunsaturated ketones were subjected to the __Clemmensen__ reduction under anhydrous conditions using amalgamated zinc, hydrogen chloride in a solution of ethyl ether, and acetic anhydride. In all cases but one the formation of cyclopropyl acetates was o
Although hydrogenolysis of conjugated (i.e., allylic or bentylic) alcohols or ketones is a well known reaction (l), the hydrogenolysis of the unconjugated carbonyl group '(e.g., I -c II) is not a recognized synthetic procedure (2). We wish to report some results, summarized in the Table, which sugge