Studies on the oncogenicity of bovine adenovirus type 3

✍ Scribed by J. H. Darbyshire; L. D. Berman; F. C. Chesterman; H. G. Pereira

• Publisher: John Wiley and Sons
• Year: 1968
• Tongue: French
• Weight: 968 KB
• Volume: 3
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910030503

✦ Synopsis

The oricogeriicity of boviric ademvirus typc~ 3 in Syrian banisters and CBA niiw has been investigated. Two diflerent pathological lesions W P ~P observed in the hamsters, but no unequivocal tunlour production was rlemonstruted in the mice. Each type of lesion in the hamisters had a diffkrent latent period and was related to the original dose of virus. Low virus doses proc/ucrxl solid characteristic adenovirus-type tumours with a latent period of at least one month, whereas higher tloses of virus characteristically produced haeniorrhagic cystic lesions incorporating ,fibroie tuniour plaques with a latent period of less than a month. The possibility that these two lesions resulted jiom the presence of two difivvnt agents in the inocula cannot be riiled out, although there is some evidencc~ to suggest that this was not the case.

Hamsters inoculated with virus deselopcd coml,lenic.rit-~xiiig, imniunodi'iising and nwtralizirig antiviral antibodies regardless of tunlour production, but an antibody response to *' T '' antigen was not consistently demonstrated. A classical transplantation immunity of the Hubc4Sjogreri type was prodirced. The cystic Irsions, although appearing as low-grade neoplasms, might actually have been partly cytotoxic (or l-vtic) in riatrrre.

Thus the persistence of sonie virions or virion antigens into the period of immunological maturity niay account for the antiviral antibody response in inoculated hamsters.