Studies on the mode of interaction of 4'-epi-adriamycin and 4-demethoxy-daunomycin with DNA
β Scribed by Terence W. Plumbridge; Jeffrey R. Brown
- Book ID
- 115773804
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 274 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0006-2952
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The interactions of the iron complexes of the anthracycline antitumour drugs daunomycin (DN) and adriamycin (ADM) with the mononucleotide AMP, herring sperm DNA, plasmic pBR322 and immortalized 3T3 fibroblasts were studied. By means of M6ssbauer spectroscopy it was demonstrated that DNA is a powerfu