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Inhibitor studies of phage T4 wild-type and mutant DNA polymerases. III. Distamycin A, actinomycin D, adriamycin, daunomycin and ethidium

✍ Scribed by J. Jantschak; Cornelia Schroeder; Dr. J. Jantschak

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
339 KB
Volume
20
Category
Article
ISSN
0233-111X

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✦ Synopsis

Abstract

Adriamycin, daunomycin and ethidium, intercalating drugs which bind to double‐ as well as single‐stranded DNA, inhibit phage T4 antimutator mutant CB121 DNA polymerase more strongly than the T4 wild‐type and the mutator L98 polymerase. In contrast, all three enzymes are inhibited equally by distamycin A and actinomycin C. The latter two inhibitors bind only to double‐stranded DNA.

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Inhibitor studies of phage T4 wild-type
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## Abstract The deoxythymidine5′‐triphosphate (dTTP) analog 3′‐fluorothymidine 5′‐triphosphate (3′‐FdTTP) inhibits DNA synthesis by T4 wild‐type, L98 (mutator) and CB121 (antimutator) DNA polymerase. CB121 DNA polymerase is less sensitive by a factor of two than the L98 and T4^+^ enzymes. Inhibitio