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Studies on the mechanisms of haloacentronitrile-induced genotoxicity IV: In vitro interaction of haloacetonitriles with DNA

✍ Scribed by A.M. Nouraldeen; A.E. Ahmed

Book ID
116153066
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
935 KB
Volume
10
Category
Article
ISSN
0887-2333

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## Abstract The haloacetonitrile, dibromoacetonitrile (DBAN), is a direct‐acting genotoxic agent that has been detected in drinking water. In a time course study, male Sprague‐Dawley rats were treated with DBAN (75 mg/kg PO), and killed at 0.5, 1, 2, and 4 hr after treatment. In a dose response stu