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Studies on the mechanism of haloacetonitriles toxicity: Inhibition of rat hepatic glutathione S-transferases in vitro

✍ Scribed by Ahmed E. Ahmed; Salah A. Soliman; Jiann-Ping Loh; G.I. Hussein

Book ID
113207390
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
770 KB
Volume
100
Category
Article
ISSN
0041-008X

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Studies on the mechanism of haloacetonit
Studies on the mechanism of haloacetonitrile-induced gastrointestinal toxicity: Interaction of dibromoacetonitrile with glutathione and glutathione-S-transferase in rats
✍ Ahmed, Ahmed E. ;Hussein, Gamal I. ;Loh, Jiann-Ping ;Abdel-Rahman, Sherif Z. πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 672 KB

## Abstract The haloacetonitrile, dibromoacetonitrile (DBAN), is a direct‐acting genotoxic agent that has been detected in drinking water. In a time course study, male Sprague‐Dawley rats were treated with DBAN (75 mg/kg PO), and killed at 0.5, 1, 2, and 4 hr after treatment. In a dose response stu