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Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. I. Generation of superoxide radical by sporidesmin

✍ Scribed by R. Munday

Book ID
113136523
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
691 KB
Volume
41
Category
Article
ISSN
0009-2797

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πŸ“œ SIMILAR VOLUMES

Studies on the mechanism of toxicity of
Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. V. Generation of hydroxyl radical by sporidesmin
✍ R. Munday πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 578 KB

Sporidesmin, the mycotoxin responsible for 'facial eczema' in ruminants, has previously been shown to generate superoxide radical and hydrogen peroxide. In the present study, the formation of the third 'active oxygen' species, hydroxyl radical, has been demonstrated. This species is produced both du

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Studies on the mechanism of toxicity of the mycotoxin sporidesmin 3β€”inhibition by metals of the generation of superoxide radical by sporidesmin
✍ R. Munday πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 490 KB

## Abstract The mycotoxin sporidesmin has previously been shown to generate superoxide radical. This reaction involves autoxidation of the reduced form of the mycotoxin, a dithiol. In the present study, a number of mercaptide‐forming metals have been shown to inhibit superoxide formation from spori

Studies on the mechanism of toxicity of
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✍ R. Munday πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 546 KB

Formation of hydrogen peroxide, the dismutation product of superoxide radical, has been demonstrated in erythrocytes incubated with the mycotoxin sporidesmin. Erythrocytic thiols, both non-protein and protein-bound, were depleted in the presence of sporidesmin, whilst haemoglobin was oxidized to met