Studies on the mechanism of action of salicylates vi: Effect of topical application of retinoic acid on wound-healing retardation action of salicylic acid

✍ Scribed by K. H. Lee; Theodore G. Tong

• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 238 KB
• Volume: 58
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600580633

✦ Synopsis

Oral administration of sodium salicylate or prednisone and topical application of salicylic acid or hydrocortisone in NIB retards healing and the inhibitory action of either one of these drugs can be reversed by local application of retinoic acid. Topical application of retinol, retinyl esters, or retinoic acid alone also promotes skin wound healing in the rat.

Keyphrases

Salicylic acid effect-wound healing 0 Hydrocortisone, predisone effect-wound healing 0 Retinoic acid effectdrug-retarded wound healing 0 Wound healing-tensile strength 1 Retinol, all trans, Sigma grade, Type X; retinyl acetate, all trans, Sigma grade, Type I; and retinoic acid, all trans, Sigma grade, Type XX, were crystalline synthetic compounds obtained from Sigma Chemical Co., St. Louis, Mo. Retinyl palmitate (Myvax) was obtained from Distillation Products Industries, Division of Eastman Kodak Co., Rochester, N. Y. Sodium salicylate, reagent grade, was obtained from J. T. Baker Chemical Co., Phillipsburg, N. J. Prednisone is a product of Upjohn Co., Kalamazoo, Mich. NonioNc base (NIB, aqueous) and 1 % hydrocortisone in M B were prepared by the Pharmaceutical Tech-