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Studies on the mechanism of action of salicylates IV: Effect of salicylates on oxidative phosphorylation

โœ Scribed by Leon Thompkins; K. H. Lee

Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
461 KB
Volume
58
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

The hydrolysis of acetylsalicylic acid and the oxidativephosphorylation uncoupling activity of salicylic acid and acetylsalicylic acid in rat liver mitochondrial preparations at pH 7.4 and 25' have been studied. The rate of hydrolysis of acetylsalicylic acid in mitochondrial preparations under these conditions is fairly slow. The uncoupling activity observed in the presence of acetylsalicylic acid is due to the salicylic acid produced during the experiment. The results obtained in the present study support some recent findings on the effect of salicylates on several other biologic activities.

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