Inhibition of deoxyhemoglobin S polymeri
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A.Seetharama Acharya; Leslie G. Sussman; Wanda M. Jones; James M. Manning
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Article
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1984
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Elsevier Science
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English
β 755 KB
Glyceraldehyde reacts with hemoglobin S in the intact erythrocyte to reduce the degree of polymerization, thereby inhibiting sickling of the erythrocyte. Only five of the 24 amino groups per C@ dimer react with glyceraldehyde; the adducts are present as ketoamine structures, formed by Amadori rearra