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Studies on the hemocompatibility of bacterial cellulose

✍ Scribed by Fábia K. Andrade; João Pedro Silva; Manuela Carvalho; Elisabete M. S. Castanheira; Raquel Soares; Miguel Gama

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
1003 KB
Volume
98A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

Among the strategies to improve a material's hemocompatibility, pre‐coating with the tripeptide Arg‐Gly‐Asp (RGD) is used to favor endothelialization thus lowering thrombogenicity. The blood compatibility of native and RGD‐modified bacterial cellulose (BC) was studied in this work for the first time. The plasma recalcification time and whole blood clotting results demonstrate the hemocompatibility of BC. A significant amount of plasma protein adsorb to BC fibres, however, according to analysis by intrinsic tryptophan fluorescence techniques when albumin, γ‐globulin, and fibrinogen from pure protein solutions adsorb to BC do not undergo detectable conformational modifications. Human microvascular endothelial cells cultured on RGD‐modified BC readily form a confluent cell layer, inhibiting the adhesion of platelets. As a general conclusion, both native and RGD‐modified BCs may be classified as hemocompatible materials. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.

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