Studies On the Elimination of Strychnine*
β Scribed by Hazleton, Lloyd W. ;Fortunato, Frank
- Publisher
- Elsevier
- Year
- 1942
- Weight
- 615 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0095-9553
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## Abstract The ^13^C n.m.r. spectra of arecoline, hordenine, strychnine, brucine and their salts were determined and the chemical shifts reported previously for arecoline have been verified by single frequency proton decoupling techniques. Effects of protonation on the carbon resonances in aiding
Strychnine, a complex molecule, antagonizes in some unknown manner the action of glycine, an important inhibitory neurotransmitter in the spinal cord and brainstem of many vertebrates. To help understand the mechanism of this antagonism, we have employed modern computational methods to assess the si