Studies on the binding mechanism of fluoroquinolones to melanin
β Scribed by M. Fukuda; Y. Morita; K. Sasaki; Y. Yamamoto
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 127 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1341-321X
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π SIMILAR VOLUMES
## Abstract We have studied the bacterial resistance to fluoroquinolones that arises as a result of mutations in the DNA gyrase target protein. Although it is known that DNA gyrase is a target of quinolone antibacterial agents, the molecular details of the quinoloneβgyrase interaction remain unclea
Drug-melanin interactions were studied using a melanin-based HPLC column. Two approaches were chosen for the preparation of the stationary phases: covalent coupling of synthetic L-dopa melanin and in situ polymerization of L-dopa. Retention of a series of phenothiazines on melanin-based stationary p