๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Studies on the antitumor agent CC-1065 : Regiospecific introduction of the oxygen functionality for the synthesis of the B/C component of CC-1065.

โœ Scribed by Philip Magnus; Serge Halazy


Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
183 KB
Volume
26
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Studies on the antitumor agent CC-1065 :
โœ Serge Halazy; Philip Magnus ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 184 KB

Sequential conjugate additions of methyl, TOSMIC anion and TOSMIC anion to I-pkenyZsuZfonyZ-1,3-butadiene provides a direct route to 3,3l-bipyrroles, andillustrates that I-pkenylsuZfonyZ-1,3-butadiene can functionas an electropkilic 1,3-butadiene equivalent. Recently we reported the synthesis of th

Alkylation of substituted pyrrole dianio
โœ Thomas A. Bryson; Gary A. Roth; Liu Jing-hau ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 229 KB

The dianion chemistry of pyrroles is investigated using several alkylating agents. Inter-followed by intramolecular alkylation with dibromoethane affords cyclopropylpyrroles 7-10. The B/C ring systems of CC-1065, a potent antitumor agentl, have been the target of several synthetic studiesz. The anti

Synthetic studies directed at the B/C ri
โœ Thomas A. Bryson; Gary A. Roth ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 222 KB

Cyclopropyl indolenones are synthesized in good overall yields. The key reaction is an intramolecular enolate ring closure giving rise to the six membered carbocyclic ring. In a previous communication we described the base induced cyclopropanation of 2,5-