Studies on the antitumor agent CC-1065 : Regiospecific introduction of the oxygen functionality for the synthesis of the B/C component of CC-1065.
โ Scribed by Philip Magnus; Serge Halazy
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 183 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Sequential conjugate additions of methyl, TOSMIC anion and TOSMIC anion to I-pkenyZsuZfonyZ-1,3-butadiene provides a direct route to 3,3l-bipyrroles, andillustrates that I-pkenylsuZfonyZ-1,3-butadiene can functionas an electropkilic 1,3-butadiene equivalent. Recently we reported the synthesis of th
The dianion chemistry of pyrroles is investigated using several alkylating agents. Inter-followed by intramolecular alkylation with dibromoethane affords cyclopropylpyrroles 7-10. The B/C ring systems of CC-1065, a potent antitumor agentl, have been the target of several synthetic studiesz. The anti
Cyclopropyl indolenones are synthesized in good overall yields. The key reaction is an intramolecular enolate ring closure giving rise to the six membered carbocyclic ring. In a previous communication we described the base induced cyclopropanation of 2,5-