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Studies on Primer Binding of HIV-1 Reverse Transcriptase Using a Fluorescent Probe

โœ Scribed by Martha D. Delahunty; Samuel H. Wilson; Richard L. Karpel

Book ID
115626509
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
651 KB
Volume
236
Category
Article
ISSN
0022-2836

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Site-directed mutagenesis has demonstrated that changes within the human immunodeficiency virus reverse transcriptase coding sequence alone can account for viral resistance to inhibitors. Inhibitor sensitivity of mutant enzymes in vitro correlates with the sensitivity of the virus to non-nucleoside