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Studies on murine sarcoma virus: antigenic characterization of murine sarcoma virus induced tumor cells

✍ Scribed by Jean-Claude Chuat; Leonard Berman; Peter Gunvén; Eva Klein

Publisher
John Wiley and Sons
Year
1969
Tongue
French
Weight
870 KB
Volume
4
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

abbreviated as MLV.

' Three different serum pools collected from the same animals. Designations such as In, 1 b, lc etc. distinguish these pools.

Rat strain obtained from Dr. Bengt Gustafsson

The cells were incubated with undiluted sera. Thereafter, rabbit complement preadsorbed with YAC cells was added in 1 :3 dilution. 5 x lo' or lo6 ceUs were plated on each dish.

Harvested from 8-day-old cultures. 5 x 10' cells subcutaneously. a No. animals with tumorjNo. inoculated (latency period in ' PO01 8. days). a Pool 5. * Summary of eight experiments in C57/Leaden, (C57/Leaden x C3H)F,, (A x CS7/Leaden) FI mice.

Two doses of 2-3 x lo6 cells 3 weeks apart followed by 350 R total body irradiation and test challenge I week later.

Two doses of los cells followed by challenge 4 weeks after the start of immunization. The mice received 350 R before test challenge

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