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Studies on Isocyanides and Related Compounds. Synthesis of Oxazole Derivatives via the Passerini Reaction

✍ Scribed by Bossio, Ricardo ;Marcaccini, Stefano ;Pepino, Roberto

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
160 KB
Volume
1991
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

The reaction between arylglyoxals (1), cyclohexyl isocyanide, and aromatic carboxylic acids (2) affords N‐cyclohexyl‐2‐acyloxy‐3‐aryl‐3‐oxopropionic amides (3) which can be cyclized to N‐cyclohexyl‐2,4‐diaryl‐5‐oxazolecarboxamides (4).

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