✦ LIBER ✦

Studies on in vitro metabolism of shikonin

✍ Scribed by Huiyi Li; Shurong Luo; Tonghui Zhou

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 54 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199905)13:3<236::aid-ptr417>3.0.co;2-f

No coin nor oath required. For personal study only.

✦ Synopsis

Shikonin is one of the active components isolated from the root of Arnebia euchrona (Royle) Johnst. It has been shown to possess significant antibacterial, antiinflammatory and antitumour activities and has been used clinically. In this paper, rat liver microsomes were incubated in vitro to study the metabolism of shikonin and a reverse-phase high performance liquid chromatography/photodiode array detector (DAD) method was used to separate and detect the metabolites. The effects of several factors on the metabolism were investigated and the metabolic system was optimized. The main metabolites were purified by RP-HPLC and their structures were determined by UV, 1 H-NMR and MS. S-1 was dihydroxylated shikonin, S-2 was 2-OH shikonin and S-3 was 6-OH or 7-OH shikonin.

📜 SIMILAR VOLUMES

Studies on the in vitro inversion of flu

Studies on the in vitro inversion of flurbiprofen

✍ Anna Lombard; Valeria Rossetti; Maria Chiara Cassone 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB 👁 2 views

This paper reports in vitro studies on the metabolic inversion of flurbiprofen (FL), an arylpropionic acid antiinflammatory agent (2-APA). The inversion was studied with both rac-FL and R-FL, by incubation with rat hepatic microsomes, in the presence of either CoASH and ATP or NADPH. The two isomers

Synthesis, in vitro metabolic studies, a

Synthesis, in vitro metabolic studies, and antitumour activity of methyl analogues of ifosfamide

✍ Konrad Misiura; Karina Kardacka; Halina Kusnierczyk 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 70 KB

Erythroleukemia: In vitro studies of ery

Erythroleukemia: In vitro studies of erythropoiesis

✍ M. M. Newcomb; L. Balducci; M. B. Coleman; M. H. Steinberg 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB

In vitro studies on clonal growth of cho

In vitro studies on clonal growth of chondrocytes in thanatophoric dysplasia

✍ Brenner, Rolf E.; Nerlich, Andreas; Terinde, Rainer; Bartmann, Peter 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 38 KB 👁 1 views

Thanatophoric dysplasia (TD) is characterized by a disorganized growth plate with markedly reduced proliferative and hypertrophic cartilage zones. Therefore, we studied in vitro the proliferation rates of articular chondrocytes from five TD patients and age-matched controls in response to bFGF, IGF-

In-vitro study on the effect of pesticid

In-vitro study on the effect of pesticides on neuronal activity

✍ Dóczi, Judit; Világi, Ildikó; Banczerowski-Pelyhe, Ilona; Örsi, Ferenc; Szentpét 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 73 KB 👁 2 views

Experiments have been conducted to examine the effect of chronic administration of bromoxynil, ¯uroxipir and bensultap on the in-vitro seizure susceptibility (induced by 4-aminopyridine) and excitability of neocortical slices of rat brain. The treatment regimes were (A) administration of spray solut

Studies on the Absorption, Residues and

Studies on the Absorption, Residues and Metabolism of Cyromazine in Tomatoes

✍ Root, Daniel S.; Hongtrakul, Tawatchai; Dauterman, Walter C. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB 👁 1 views

The residues and metabolism of radio-labeled cyromazine ( Ncyclopropyl-l,3,5-triazine-2,4,6-triamine) formulated as a 750 g kg-' WP ('Trigard' 75WP)@ was studied in greenhouse tomatoes. Residues of cyromazine and its metabolites were remarkably persistent, with only a slight loss occurring within a