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In-vitro study on the effect of pesticides on neuronal activity

✍ Scribed by Dóczi, Judit; Világi, Ildikó; Banczerowski-Pelyhe, Ilona; Örsi, Ferenc; Szentpétery, Zsolt

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
73 KB
Volume
55
Category
Article
ISSN
1526-498X

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✦ Synopsis

Experiments have been conducted to examine the effect of chronic administration of bromoxynil, ¯uroxipir and bensultap on the in-vitro seizure susceptibility (induced by 4-aminopyridine) and excitability of neocortical slices of rat brain. The treatment regimes were (A) administration of spray solution in place of drinking water for seven days, and (B) feeding wheat which had been sprayed at growth stage Feekes 9±10 and consumed four to six weeks after spraying. The latency of appearance of the ®rst seizure was signi®cantly increased by ¯uroxipir (B) bensultap (B) and bromoxynil (A&B). Fluroxipir (A&B) decreased the frequency of seizure, and ¯uroxipir (A) and bensultap (B) doubled the duration of seizures. Excitability following electrical stimulation of the corpus callosum was not signi®cantly changed by any treatments. The changes in brain activity were not related to the residue levels of the pesticides in the rat brains. Our results suggest that these chemicals may alter the functional properties of neuronal network activity and neurotransmission in rat neocortex after environmental exposure.

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