Studies on carcinogenesis by avian sarcoma viruses. VI. Differential multiplication of uninfected and of converted cells in response to insulin

✍ Scribed by Howard M. Temin

• Publisher: John Wiley and Sons
• Year: 1967
• Tongue: English
• Weight: 661 KB
• Volume: 69
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1040690314

✦ Synopsis

Insulin can replace the factor(s) in calf serum whose amount is limiting for multiplication in cell culture of chicken embryo fibroblasts and of chicken embryo fibroblasts infected and converted by avian sarcoma virus. In serum-free, insulincontaining medium, converted cells multiply more than do uninfected cells. It appears, therefore, that the increased multiplication in cell culture of converted cells as compared with uninfected cells results from a decreased requirment by the converted cells for an insulin-like activity found in serum.

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