𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Studies on adrenergic mechanisms in the action of desmethyl imipramine (DMI)

✍ Scribed by Zbigniew S. Herman

Publisher
Springer
Year
1970
Tongue
English
Weight
428 KB
Volume
17
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

The influence of a-methyl tyrosine and diethyldithiocarbamate which specifically inhibit noradrenaline synthesis and the influence of p-chlorophenylalanine which inhibits 5-hydroxytryptamine synthesis in the brain on the antagonism between desmethylimipramine and RO 4-1284 was studied. It was shown that both substances which inhibit noradrenaline synthesis abolish the behavioural antagonism between DMI and 1~O 4-1284, and p-chlorophenylalanine is without effect on this antagonism. The evidence shows that DMI antagonises the action of a benzoqninolizine derivative by the participation of adrenergie mechanisms.

πŸ“œ SIMILAR VOLUMES

Studies on the mechanisms of action of B
Studies on the mechanisms of action of BCG
✍ I. Florentin; R. Huchet; M. Bruley-Rosset; O. Halle-Pannenko; G. MathΓ© πŸ“‚ Article πŸ“… 1976 πŸ› Springer-Verlag 🌐 English βš– 872 KB
Studies on the mechanism of biotin actio
Studies on the mechanism of biotin action
✍ Howard J. Schaeffer; Parmatma S. Bhargava πŸ“‚ Article πŸ“… 1962 πŸ› John Wiley and Sons 🌐 English βš– 194 KB πŸ‘ 1 views
Role of beta-adrenergic receptors in the
Role of beta-adrenergic receptors in the mechanism of action of second-generation antidepressants
✍ Vimala H. Sethy; Douglas W. Harris πŸ“‚ Article πŸ“… 1982 πŸ› John Wiley and Sons 🌐 English βš– 256 KB πŸ‘ 1 views

## Abstract The effect of chronic intravenous infusion of desmethylimipramine (DMI), amitriptyline, mianserin, bupropion, alprazolam, or diazepam on the density of beta‐adrenergic receptors in the rat cerebral cortex has been investigated in this study. DMI and amitriptyline significantly decreased

Studies on the mechanism of action of cy
Studies on the mechanism of action of cytosine arabinoside
✍ Kufe, D. W. ;Major, P. P. πŸ“‚ Article πŸ“… 1982 πŸ› John Wiley and Sons 🌐 English βš– 944 KB

We have demonstrated that Ara-C incorporates in leukemic cell DNA and that the extent of this incorporation correlates significantly with loss of clonogenic survival. This relationship between formation of (Ara-C)DNA and cytotoxicity is also obtained in the presence of modulating agents such as thym