๐”– Bobbio Scriptorium
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Role of beta-adrenergic receptors in the mechanism of action of second-generation antidepressants

โœ Scribed by Vimala H. Sethy; Douglas W. Harris

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
256 KB
Volume
2
Category
Article
ISSN
0272-4391

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โœฆ Synopsis

Abstract

The effect of chronic intravenous infusion of desmethylimipramine (DMI), amitriptyline, mianserin, bupropion, alprazolam, or diazepam on the density of betaโ€adrenergic receptors in the rat cerebral cortex has been investigated in this study. DMI and amitriptyline significantly decreased the density of betaโ€adrenergic receptors. Mainserin, bupropion, alprazolam, and diazepam had no significant effect on the density of betaโ€adrenergic receptors. Results of this study indicate that mechanisms other than betaโ€adrenergic receptors may be involved in the antidepressant activity of these drugs.

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