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Studies on a gross-virus-induced lymphoma in the rat. III. Optimisation, specificity and applications of the in vitro immune response

✍ Scribed by J. Bruce; N. A. Mitchison; G. R. Shellam

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
649 KB
Volume
17
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Conditions are described for optimal stimulation in vitro of lymphocytes from rats primed in vivo with syngeneic MuLV‐G leukaemia cells. Cultures generate effector cells which show high cytotoxic activity against leukaemic cells. Specific stimulation can be obtained with leukaemic cells and with disrupted MuLV. Leukaemic cells, normal spleen cells and the viron internal protein p30 competitively inhibit effector cells, but purified virus exerts nonspecific inhibition. These findings are interpreted as supporting the hypothesis that virion antigens constitute a major target of anti‐tumour cytotoxic immunity.

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