𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cell-mediated reaction against tumors induced by oncornaviruses. I. Kinetics and specificity of the immune response in Murine sarcoma virus (MSV)-induced tumors and transplanted lymphomas

✍ Scribed by J. C. Leclerc; E. Gomard; J. P. Levy

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
781 KB
Volume
10
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Anti‐tumour cell‐mediated immune reactions were studied by the chromium release test (CRT) in mice bearing autochtonous Murine Sarcoma Virus (MSV)‐induced sarcomas or syngeneic transplants of lymphomas with various antigenic specificities. Cytotoxic lymphoid cells were detected during tumor growth, but disappeared rapidly after day 13–15 in “progressors”, and more slowly in mice which were able to reject the tumor (“regressors”). The level of cytolytic activity of lymphoid cells in the spleen of “regressors” did not parallel the immune protection. No blocking of the cytotoxic activity of lymphoid cells was detected in CRT using either “progressor”, or “regressor” sera. The discrepancies which exist between these results and those which were obtained in the same tumor system by colony inhibition test or microcytotoxicity assay may suggest that different phenomena, possibly involving different lymphoid cell populations, were studied by the various methods. The antigenic specificity of the immune reactions which were evidenced by the CRT was not identical to those revealed by serological methods, cross‐reactivity being regularly observed in CRT between FMRGi+ and G+lymphomas.

📜 SIMILAR VOLUMES

Cell-mediated immune reaction against tu
Cell-mediated immune reaction against tumors induced by oncornaviruses. II. Nature of the effector cells in tumor-cell cytolysis
✍ J. C. Leclerc; E. Gomard; F. Plata; J. P. Levy 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 French ⚖ 514 KB

## Abstract The nature of the effector cells detected by the chromium release test (CRT) has been studied in BALB/c and C57Bl/6 mice bearing murine sarcoma virus (MSV)‐induced tumors. Anti‐θ‐C3H immune sera completely inhibited the cytotoxic activity of lymphoid cells in the presence of complement;