𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cell-mediated immune reaction against tumors induced by oncornaviruses. II. Nature of the effector cells in tumor-cell cytolysis

✍ Scribed by J. C. Leclerc; E. Gomard; F. Plata; J. P. Levy

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
514 KB
Volume
11
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The nature of the effector cells detected by the chromium release test (CRT) has been studied in BALB/c and C57Bl/6 mice bearing murine sarcoma virus (MSV)‐induced tumors. Anti‐θ‐C3H immune sera completely inhibited the cytotoxic activity of lymphoid cells in the presence of complement; anti‐immunoglobulin sera failed to decrease this activity. No activation of normal non‐sensitized lymphoid cells in the presence of heat‐decomplemented sera from mice bearing MSV‐induced sarcomas could be obtained. Identical results have been found in allogeneic systems with major H‐2 histocompatibility antigens. It can be concluded that a thymus‐processed lymphoid cell sub‐population sharing the θ antigen is exclusively or very predominantly responsible for the immune cytolysis both in syngeneic tumor systems and in allogeneic transplantation systems.

📜 SIMILAR VOLUMES

Cell-mediated immune reaction against tu
Cell-mediated immune reaction against tumors induced by oncornaviruses. III. Studies by mixed lymphocyte—tumor reaction
✍ A. Senik; E. Gomard; F. Plata; J. P. Levy 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 French ⚖ 565 KB

## Abstract A one way mixed lymphocyte—tumor‐cell reaction (MLTR)‐was applied to the study of anti‐tumor cell‐mediated immunity in MSV‐infected mice. No stimulation of normal, non‐immune lymphocytes by tumor cells was observed. Lymphoid cells which can be stimulated in vitro by various tumor cells

Cell-mediated reaction against tumors in
Cell-mediated reaction against tumors induced by oncornaviruses. I. Kinetics and specificity of the immune response in Murine sarcoma virus (MSV)-induced tumors and transplanted lymphomas
✍ J. C. Leclerc; E. Gomard; J. P. Levy 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 French ⚖ 781 KB

## Abstract Anti‐tumour cell‐mediated immune reactions were studied by the chromium release test (CRT) in mice bearing autochtonous Murine Sarcoma Virus (MSV)‐induced sarcomas or syngeneic transplants of lymphomas with various antigenic specificities. Cytotoxic lymphoid cells were detected during t

Cell-mediated anti-tumor immunity in onc
Cell-mediated anti-tumor immunity in oncorna virus-induced tumors: Specific cytostasis of tumor cells by spleen and lymph-node cells
✍ A. Senik; L. De Gioroi; J. P. Levy 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 615 KB

## Abstract The cytostatic effect of lymphoid cell (LC) suspensions from MSV‐induced tumorbearing mice has been tested in the “cytostasis assay” (CA) according to Chia and Festenstein (1973). The target cells (TC) were syngeneic lymphoma cells in suspension. Specific cytostasis was observed mainly

Cellular basis for the immune response t
Cellular basis for the immune response to methylcholanthrene-induced tumors in mice. Heterogeneity of effector cells
✍ R. Kearney; A. Basten; D. S. Nelson 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 914 KB

## Abstract Immune resistance to methylcholanthrene‐induced tumors has two phases, an early specific and a late non‐specific phase. Both phases were found to be T‐cell‐dependent in vivo. Thus, adult thymectomized, irradiated, bone‐marrow‐protected mice bearing H‐1 tumor isografts showed impaired re

Dendritic epidermal T-cell involvement i
Dendritic epidermal T-cell involvement in induction of CD8+ T cell-mediated immunity against an ultraviolet radiation-induced skin tumor
✍ Lois L. Cavanagh; Ross StC. Barnetson; Antony Basten; Gary M. Halliday 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 176 KB 👁 2 views

Murine epidermis contains 2 distinct cell populations which contribute to the skin immune system, Langerhans cells (LC), and dendritic epidermal T cells (DETC). LCs are important in the induction of immunity against a wide range of antigens; however, the function of DETC is unclear. To investigate t