1H NMR Study of Conformational Differenc
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Robert Glaser; Gregory J. Tarrant; John B. Bremner
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Article
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1997
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John Wiley and Sons
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English
β 275 KB
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The stereochemistry of bicyclic oxazepane-type intermediates for the synthesis of hydroxylated tropane alkaloids was determined by 1H NMR spectroscopy. Thermolysis of the 3a-tert-butyldimethylsiloxy-8-methyl-8azabicyclo [ 3.2.1 ] oct-6-ene axial N-oxide diastereomer (1) in butyronitrile a β orded the