Studies of the rad-equivalence of ethylene oxide in the presence and absence of 12-O-tetradecanoylphorbol-13-acetate (TPA) in C3H/ 10T1/2 cells
✍ Scribed by Kolman, Ada; Näslund, Maria; Osterman-Golkar, Siv
- Book ID
- 121780004
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 459 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0378-4274
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## Abstract In the present work, we have inspected expression of estrogen receptors (ER) and their regulation by the phorbol diester 12‐O‐tetradecanoylphorbol 13‐acetate (TPA) in a leukemic cell line, the THP‐1 cells, using multiple experimental approaches. Firstly, ligand binding assay (LBA) revea
Results from nuclear run-off assays show that exposure of hepatocytes and Reuber H35B hepatoma cells to the tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), leads to enhanced transcription of c-Ki-ras gene. This increase in transcription in turn results in an accumulation of the function