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Studies of the intermediates in the folding of ribonuclease A

โœ Scribed by Kim, Peter S.; Cook, Kem H.; Baldwin, Robert L.


Book ID
118517779
Publisher
Biophysical Society
Year
1980
Tongue
English
Weight
163 KB
Volume
32
Category
Article
ISSN
0006-3495

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Further experimental studies of the disu
โœ Steven J. Wearne; Thomas E. Creighton ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 932 KB

Two very different mechanisms of folding have been proposed from experimental studies of disulfide formation in reduced ribonuclease A. (1) A pathway in which the rate-limiting step separates fully folded protein from all other disulfide intermediates and occurs solely in three-disulfide intermediat