## Abstract A significant biochemical change that takes place in intervertebral disc degeneration is the loss of proteoglycans in the nucleus pulposus. Proteoglycans attract fluid, which works to reduce mechanical stresses in the solid matrix of the nucleus and provide a hydrostatic pressure to the
Studies of the human intervertebral disc
โ Scribed by F. Happey
- Publisher
- Elsevier Science
- Year
- 1970
- Tongue
- English
- Weight
- 965 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0014-3057
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โฆ Synopsis
Results obtained by physical methods of examination, particularly X-ray diffraction, polarizing and electron microscopy and more recently differential thermal analysis, are reviewed. The different structures of the elastic wall of the disc (annulus fibrosus) and the gel-like centre of the disc (nucleus pulposus) are described in relation to their functions. An important component of aged nucleus pulposus is a substance giving an X-ray diffraction spacing of 4.7 A, presumably a denatured protein in the ~-form, but its origin is still obscure. The value of differential thermal analysis in the study of collagen of the disc and other connective tissues is illustrated.
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