✦ LIBER ✦

Studies of cytogenetic effects of sodium arsenicals on mammalian cells in vitro

✍ Scribed by Wan, Bojian ;Christian, Robert T. ;Soukup, S. W.

Publisher: Wiley (John Wiley & Sons)
Year: 1982
Weight: 303 KB
Volume: 4
Category: Article
ISSN: 0192-2521
DOI: 10.1002/em.2860040408

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The cytotoxic and cytogenetic effect of sodium arsenite and sodium arsenate on Chinese hamster ovary (CHO) cells is reported. Chromosome aberrations were induced with both arsenic compounds. Trivalent arsenic was more clastogenic than pentavalent arsenic. Sodium arsenite was also shown to produce increased sister chromatid exchange in CHO cells and increased chromosome breakage in human lymphocytes.

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