Studies of benzoxazines 16*. Synthesis and reactivity of 2,4-substituted 4H-3,1-benzoxazines
✍ Scribed by E. V. Gromachevskaya; V. G. Kul’nevich; T. P. Kosulina
- Book ID
- 113063742
- Publisher
- Springer US
- Year
- 2012
- Tongue
- English
- Weight
- 363 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0009-3122
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📜 SIMILAR VOLUMES
Various 3-substituted-4H-1,4-benzoxazines were prepared in good yields by lithiation-electrophilic substitution of the 4-Boc-4H-l,4-benzoxazine. The synthesis of this carbamic derivative, in four steps from 2aminophenol, was described.
Two new and efficient synthetic routes towards substituted 4H-1,4-benzoxazine derivatives were reported. The first one involves the synthesis in four steps of the 4-Boc-4H-1,4-benzoxazine and its regioselective substitution on C-3 following a lithiation-electrophilic substitution sequence. The secon