Studies into Asymmetric Catalysis of the Nozaki–Hiyama Allenylation

✍ Scribed by Masahiro Inoue; Masahisa Nakada

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 115 KB
• Volume: 118
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.200502871

✦ Synopsis

The allene moiety represents a versatile and useful functional group in organic synthesis because of its unique reactivity. [1] Recent developments in the chemistry of allenes suggest that allenic alcohols are important synthetic intermediates because they can be stereoselectively converted into compounds with other functional groups, for example, the amino alcohols [2] and 2,5-dihydrofurans, [1a, 3] and they can also be used as substrates for Pauson-Khand reactions [1a, 4] and Pdmediated reactions. [1a, 5] Allenic alcohols are generally prepared by allenylation of carbonyl compounds, [1b, e, 6] and chiral ones have been elaborated by asymmetric synthesis. [1a, 7, 8] Among the enantioselective methods, catalytic asymmetric synthesis [1a, 9] is important