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Studies directed toward synthesis of quassinoids - I. Conversion of cholic acid to a δ-lactone

✍ Scribed by Jerry Ray Dias; R. Ramachandra

Publisher: Elsevier Science
Year: 1976
Tongue: French
Weight: 107 KB
Volume: 17
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)93081-8

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✦ Synopsis

The broad spectrum of biological propertiesI, including antileukemic activity', associated with quassinoid related principles from the plant family Simmubaeeae has attracted considerable interest. 3 Prompted by the suggestion that the conjugated ketone in the A-ring of quassinoids may play an active role in their mechanism of biological action4, one research group has simulated the diosphenol system of quassinoids by incorporating it in the A-ring of an androstane skeletone5 Another group has recently communicated their preliminary results toward the synthesis of quassin starting with a Diels-Alder reaction as the intial step.6 The purpose of this communication is to report

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