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Structures of the two 3D domain-swapped RNase A trimers

✍ Scribed by Yanshun Liu; Giovanni Gotte; Massimo Libonati; David Eisenberg

Book ID
119824651
Publisher
Cold Spring Harbor Laboratory Press
Year
2009
Tongue
English
Weight
675 KB
Volume
11
Category
Article
ISSN
0961-8368

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✍ Nan Zhong; Shengnan Zhang; Fei Xue; Xue Kang; Peng Zou; Jiaxuan Chen; Chao Liang πŸ“‚ Article πŸ“… 2009 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 431 KB

## Abstract SARS coronavirus main protease (M^pro^) plays an essential role in the extensive proteolytic processing of the viral polyproteins (pp1a and pp1ab), and it is an important target for anti‐SARS drug development. We have reported that both the M^pro^ C‐terminal domain alone (M^pro^‐C) and