✦ LIBER ✦

Structures of the major human metabolites of docetaxel (RP 56976 - Taxotere®)

✍ Scribed by B. Monegier; C. Gaillard; S. Sablé; M. Vuilhorgne

Book ID: 104214304
Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 271 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73079-6

No coin nor oath required. For personal study only.

✦ Synopsis

AbtMtlU:ThC-of the main hwnan merabolitc~ ef doataxel (RP ~97~T~) isolated from human faces have been estdihd using HPLC/MS-MS and 6OOMHz N?dR expcrimeMs. Them mctabolitcs Bit C-13 side Chain oxidation derivatives of the parw* compound. Docetaxel 1 (RP 56976, Taxotere@) is a semisynthetic compound obtained via direct acylation at the C-13 position of lo-deacetyl baccatin III (DAB) extracted &rn the leaves of Tm baccata L. l. Docetaxel as well as paclitaxel (TaxolQD) are currently cun&dered as among the most promising drugs in Cancer Research *_ Docetaxel in&f&es with the ~~~~e -tubulin system in eukaryotic cells. It shows excellent anti-tumor activity and is actually in phase II clinical trials.

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