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Structures of OA-6129A, B1, B2 and C, new carbapenem antibiotics

✍ Scribed by Takeo Yoshioka; Ikuo Kojima; Kunio Isshiki; Azuma Watanabe; Yasutaka Shimauchi; Mitsuyasu Okabe; Yasuo Fukagawa; Tomoyuki Ishikura

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
220 KB
Volume
23
Category
Article
ISSN
0040-4039

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✦ Synopsis

The structures of carbapenems OA-6129A, B,, B2 and C were determlned by spectroscopy and chemical transformation In the course of our extensive work on carbapenems, B2($) and C($,)') new compounds OA-6129A(l), Bl($), have been isolated as sodium salts from Streptmyces sp. OA-6129 These compounds showed potent antlmlcroblal activity against Gram-posltlve and -negative bacteria2 and inhibitory activity to &lactamases In this communication, we report the structure determination of the antibiotics by means of spectroscopic analysis, chemical degradation

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