Structures of new metabolites of diacetoxyscirpenol in the excreta of orally administered rats
β Scribed by Sakamoto, Tae; Swanson, Steven P.; Yoshizawa, Takumi; Buck, William B.
- Book ID
- 126250478
- Publisher
- American Chemical Society
- Year
- 1986
- Tongue
- English
- Weight
- 580 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0021-8561
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## 2-[S-(N-Acetyl )cysteine]-isopropylacetanilide sulfoxide was isolated from the excreta of germfree rats given oral doses of 2-chloro-N-isopropylacetanilide. The metabolite was characterized by mass and nuclear magnetic resonance spectrometry on samples isolated from rats dosed with [l-"C]and [2
## Abstract Adult male rats receiving styrene by gavage (200 or 400 mg kg^β1^, 6 days a week) for 100 days exhibited a significant doseβdependent increase in hepatic benzo[__a__]pyrene hydroxylase and ammopyrineβ__N__βdemethylase, a decrease in glutathioneβ__S__βtransferase and no change in glucose