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Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

✍ Scribed by Yano, Jason K; Hsu, Mei-Hui; Griffin, Keith J; Stout, C David; Johnson, Eric F


Book ID
109967007
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
225 KB
Volume
12
Category
Article
ISSN
1545-9993

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## Abstract The kinetic analysis of coumarin oxidation by CYP2A6 suggested that substrate binding and release occurred in the multiple steps and such events proceeded rapidly. However, the crystal structure of the CYP2A6‐coumarin complex reveals that no obvious channel is open enough to allow couma