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Structure/function studies of phosphoryl transfer by phosphoenolpyruvate carboxykinase

✍ Scribed by Louis T.J. Delbaere; Athena M. Sudom; Lata Prasad; Yvonne Leduc; Hughes Goldie

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
673 KB
Volume
1697
Category
Article
ISSN
1570-9639

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## Abstract A cyclin‐dependent kinase, Cdk2, catalyzes the transfer of the γ‐phosphate from ATP to a threonine or serine residue of its polypeptide substrates. Here, we investigate aspects of the reaction mechanism of Cdk2 by gas‐phase density functional calculations, classical molecular dynamics,