hototropic tautomerkm in 4-quinolone-3-carboxylic acid derivatives has been studied with particular emphasis on the intluence of the ring substituents on the equilibrium. The techniques used include W. 1H-NMR. 13C-NMR (soluttonl and 13C-NMR CP/MAS (solid state) and semiempirical and ab tnltio calcul
Structure—Function relationships in a series of 4-quinolone-3-carboxylic acid derivatives
✍ Scribed by M. V. Shul'gina; N. I. Fadeeva; T. N. Bol'shakova; I. B. Levshin; R. G. Glushkov
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 489 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0091-150X
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New quinolones 3, 6 and 9 mmelated to either a 5-raembered or a 6-membered lactone were designed as hybrids of antibacterial 4-quinolones and antitumor epipodophyllotoxin derivatives. They were synthezised using ethyl 2-ethenyl-4-hydroxy-l,2-dihydroquinoline-3-carboxylate 2 as a key intermediate.
## Abstract 3,4‐Dihydroxycinnamic acid (caffeic acid, CAF) is a natural product containing a catechol group with an α,β‐unsaturated carboxylic acid chain that has shown hepatoprotective properties. The aim of this work was to determine the importance of the 4‐hydroxy, 3‐hydroxy, 3,4‐dihydroxy subst