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Structured Triglyceride Vehicles for Oral Delivery of Halofantrine: Examination of Intestinal Lymphatic Transport and Bioavailability in Conscious Rats

✍ Scribed by René Holm; Christopher J. H. Porter; Anette Müllertz; Henning G. Kristensen; William N. Charman


Book ID
110394458
Publisher
Springer US
Year
2002
Tongue
English
Weight
128 KB
Volume
19
Category
Article
ISSN
0724-8741

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The contribution of lymphatic transport and absorption directly into the portal blood to the overall oral bioavailability of a model lipophilic drug, halofantrine (Hf), was determined in lymph-cannulated, conscious, unrestrained rats after administration in lipidic vehicles with different fatty acid