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Structure–affinity relationships for the binding of actinomycin D to DNA

✍ Scribed by José Gallego; Angel R. Ortiz; Beatriz de Pascual-Teresa; Federico Gago

Book ID
110257526
Publisher
Springer Netherlands
Year
1997
Tongue
English
Weight
832 KB
Volume
11
Category
Article
ISSN
0920-654X

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Actinomycin-D (actD) binds to natural DNA at two different classes of binding sites, weak and strong. The affinity for these sites is highly dependent on DNA sequence and solution conditions, and the interaction appears to be purely entropic driven. Although the entropic character of this reaction h