𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061

✍ Scribed by Llinàs-Brunet, Montse; Bailey, Murray D.; Bolger, Gordon; Brochu, Christian; Faucher, Anne-Marie; Ferland, Jean Marie; Garneau, Michel; Ghiro, Elise; Gorys, Vida; Grand-Maître, Chantal; Halmos, Ted; Lapeyre-Paquette, Nicole; Liard, Francine; Poirier, Martin; Rhéaume, Manon; Tsantrizos, Youla S.; Lamarre, Daniel


Book ID
124101461
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
77 KB
Volume
47
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


The design of a potent inhibitor of the
✍ Youla S. Tsantrizos 📂 Article 📅 2004 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 858 KB

## Abstract The virally encoded serine protease NS3/NS4A is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis, cirrhosis of the liver, and hepatocellular carcinoma. Until very recently, the design of inhibitors for the HCV NS3 protease