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Structure−Activity Studies of Antitumor Agent Irofulven (Hydroxymethylacylfulvene) and Analogues

✍ Scribed by McMorris, Trevor C.; Yu, Jian; Lira, Ricardo; Dawe, Robin; MacDonald, John R.; Waters, Stephen J.; Estes, Leita A.; Kelner, Michael J.


Book ID
118254419
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
76 KB
Volume
66
Category
Article
ISSN
0022-3263

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## Abstract The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monoca